Every few years, a new, innovative drug emerges that claims to address all your ailments. But none has taken the medical industry by storm like glucagon-like peptide-1 receptor agonists — or GLP-1. What first started as a diabetes-treating drug has quickly become the most common drug for weight loss.
GLP-1 is different from all other medications because it mimics a hormone your body naturally produces. It’s heavily backed by numerous studies, participants, and scientists. More importantly, doctors are finding that GLP-1s aren’t just helping people with type 2 diabetes and their weight, but they’re also noticing that by losing weight, patients are showing improved immune systems and overall better mental health.
As of 2023, clinical studies have shown that certain GLP-1 medications (such as GLP-1) can help patients achieve an average weight loss of 10-15 percent of their body weight when combined with lifestyle changes. With the obesity rate in the U.S. reaching over 40 percent of adults, according to the CDC, it’s no surprise that many people are considering these medications as a potential option.
According to Dr. Garrett Garner, lead physician at SimpleFixRx, “We’ve seen remarkable improvements in blood sugar control and overall health when GLP-1 therapy is introduced alongside a patient’s commitment to healthier lifestyle habits.”
What are GLP-1s?
GLP-1s are a class of medications that mimic a hormone your body naturally produces to help regulate blood sugar, control appetite, and slow gastric emptying. First used primarily to treat type 2 diabetes, these drugs have gained significant attention for their weight management benefits, as many patients taking them for blood sugar noticed considerable reductions in appetite and gradual weight loss.
The numbers behind GLP-1s
Blood sugar control
According to a 2022 meta-analysis (recently updated in 2024), GLP-1 receptor agonists can lower hemoglobin A1c levels (a measure of long-term blood sugar) by approximately 1.0-1.5 percentage points compared to a placebo or alternative treatments.
Weight loss
In a large trial completed in 2021, researchers reported that participants taking one of the newer GLP-1 medications experienced an average weight loss of 14.9 percent over 68 weeks. These findings reinforced the potential of GLP-1s as a significant tool for those struggling with obesity.
Cardiovascular benefits
Some GLP-1 medications have also been linked to a lower risk of cardiovascular events in patients with type 2 diabetes, including reductions in the incidence of heart attacks and strokes.
What makes someone a good candidate?
Dr. Garner states, “While many people can benefit from GLP-1 receptor agonists for weight management or type 2 diabetes, they’re not suitable for everyone. We consider each patient’s unique medical profile, including any history of gastrointestinal issues or other chronic illnesses. For women who are or might become pregnant, we carefully review available safety data before making any recommendations.”
So, what makes a good candidate for GLP-1 medications?
- Type 2 diabetes: GLP-1s are approved for blood glucose management in type 2 diabetes. If your blood sugar levels remain difficult to control despite lifestyle modifications, your doctor may suggest a GLP-1 as part of your treatment plan.
- Obesity or overweight with comorbidities: If you have a body mass index (BMI) indicating obesity (30 or higher) or you are overweight (BMI of 25–29.9) with additional health issues such as hypertension, high cholesterol, or prediabetes, GLP-1s might be an option.
- Other approaches haven’t worked: Sometimes, diet and exercise alone aren’t enough to bring about meaningful weight loss for individuals with significant metabolic challenges. In such cases, GLP-1s may serve as a jump-start toward healthier living.
- Motivation for ongoing lifestyle changes: GLP-1s are most effective when combined with sustainable lifestyle changes, namely improved nutrition and increased physical activity.
The importance of personalized medical advice
Dr. Garner emphasizes that there’s no one-size-fits-all approach to health, especially in fields like obstetrics and gynecology. “It’s important to have a thorough conversation with your healthcare provider,” he says. “In my practice, we look at diet, exercise, mental health, and a patient’s desire for future fertility. Together, we map out a treatment plan that truly aligns with their goals and lifestyle.”
It’s also key to remember that GLP-1 therapy, like other medical treatments, should be part of a comprehensive health strategy. Regular checkups, blood tests, and possibly consultations with specialists (such as dietitians or endocrinologists) may all be necessary to monitor your progress safely and effectively.
As more research emerges and new formulations become available, GLP-1 receptor agonists continue to show promise for people looking to better manage type 2 diabetes or reduce excess weight. From improved blood sugar control to notable weight loss outcomes, the data up to 2024 highlights their growing importance in modern medicine.
Still, deciding if these medications are right for you requires professional guidance. “With the support of an experienced physician,” notes Dr. Garner, “you can weigh the pros and cons of GLP-1 therapy, assess your personal health goals, and develop a plan tailored specifically to your needs.”
SimpleFixRx now carries GLP Squared, a combination of GLP-1 and GLP/GIP together. This helps when patients stall or need a jumpstart. It also allows microdosing. Speak with one of the providers at SimpleFixRx today and see if GLP Squared is right for you.
Remember, it’s never just about the medication — your overall lifestyle, family planning considerations, and ongoing medical support are all critical factors in achieving lasting health.